Research at the Níhí Lab is guided by an Indigenous-Centered Research Framework, inspired by lessons from Tó (water in Diné). Like rivers, the framework reflects how Systems-based thinking is be dynamic, adaptable, and considerate of the ripple of change. Combining Indigenous Knowledge and Research Protocols with Place, Space, fundamental Diné philosophy and Family/Core values leads to the grander foundation of Indigenous Data Sovereignty. Dr. Cherie DeVore has over a decade of experience with several Native communities in the Western U.S. Community. This toolkit utilizes tangible and intangible tools (physical and metaphysical) that expand the definition of science and science communication—with the foundation of Indigenous Systems of Knowledge (ISK) and the Three Rs of Respect, Responsibility, and Reciprocity. A connecting objective to the toolkit centers “relationality,” sustainability and community above novelty.